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Adipose tissue

A collection of fat cells.


The following content matched the glossary term: Adipose tissue

Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults

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Neeland IJ, Turer AT, Ayers CR, Powell Wiley TM, Vega GL, Farzaneh Far R, Grundy SM, Khera A, McGuire DK, de Lemos JA. Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults. JAMA. 2012;308(11):1150-1159. The risk of type 2 diabetes mellitus is heterogeneous among obese individuals. Factors that discriminate prediabetes or diabetes risk within this population have not been well characterized.

Pleiotropic effects of rimonabant: clinical implications

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Després JP. Pleiotropic effects of rimonabant: clinical implications. Curr Pharm Des. 2009;15(5):533-570. Abdominal obesity (high waist circumference) is more strongly associated with cardiovascular disease and type 2 diabetes than generalized adiposity (high body mass index).

Prevention of weight gain in adult patients with type 2 diabetes treated with pioglitazone

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Kushner RF, Sujak M. Prevention of weight gain in adult patients with type 2 diabetes treated with pioglitazone. Ophthalmology. 2009 Jan 29. [Epub ahead of print]. Pioglitazone, a thiazolidinedione (TZD) commonly used to treat type 2 diabetes, is associated with weight gain. Our study was designed to examine the effectiveness of three lifestyle-treatment programs of varying intensity on prevention of pioglitazone-induced weight gain and to measure the composition of the change in body weight.

The incretins: From the concept to their use in the treatment of type 2 diabetes. Part A: Incretins: Concept and physiologic functions

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Girard J. The incretins: From the concept to their use in the treatment of type 2 diabetes. Part A: Incretins: Concept and physiologic functions. Diabetes Metab. 2008;34(6):550-559. This paper briefly reviews the concept of incretins and describes the biological effects of the two incretins identified so far: the glucose-dependent insulinotropic polypeptide (GIP); and the glucagon-like peptide-1 (GLP-1). GIP is released by the Kcells of the duodenum, while GLP-1 is released by the Lcells of the distal ileum, in response to nutrient absorption.

Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobilization and oxidation in yype 2 diabetic patients

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Boschmann M, Engeli S, Dobberstein K, et al. Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobilization and oxidation in type 2 diabetic patients. J Clin Endocrinol Metab. 2008 Dec 16. [Epub ahead of print]. Dipeptidyl-peptidase-IV (DPP-4) inhibition increases endogenous GLP-1 activity resulting in improved glycemic control in patients with type 2 diabetes mellitus.

Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

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Bakker W, Eringa EC, Sipkema P, van Hinsbergh VW. Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity. ACC Abstracts of the 48th Scientific Session. Cell Tissue Res. 2009;335(1):165-189. Endothelial dysfunction comprises a number of functional alterations in the vascular endothelium that are associated with diabetes and cardiovascular disease, including changes in vasoregulation, enhanced generation of reactive oxygen intermediates, inflammatory activation, and altered barrier function.

Mechanisms linking obesity to insulin resistance and type 2 diabetes

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Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444:840-846. Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in the development of insulin resistance.

Lipotoxicity versus adipotoxicity-The deleterious effects of adipose tissue on beta cells in the pathogenesis of type 2 diabetes

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Eldor R, Raz I. Lipotoxicity versus adipotoxicity-The deleterious effects of adipose tissue on beta cells in the pathogenesis of type 2 diabetes. Diabetes Res Clin Pract. 2006;74(2 Suppl):S3-S8. Type 2 diabetes (T2D) is thought to be a culmination of two seemingly distinct processes, insulin resistance and beta cell failure, both of which have been closely linked to obesity. Here, we focus on the various deleterious effects of obesity on the beta cell.

Inverse correlation between serum adiponectin concentration and hepatic lipid content in Japanese with type 2 diabetes

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Maeda K, Ishihara K, Miyake K, Kaji Y, Kawamitsu H, Fujii M, Sugimura K, Ohara T. Inverse correlation between serum adiponectin concentration and hepatic lipid content in Japanese with type 2 diabetes. Metabolism. 2005;54:775-780. Abstract Adiponectin is an adipose tissue-specific protein and plays an important role in insulin sensitivity. On the other hand, intramyocellular lipid content and hepatic lipid content (HLC) are related to insulin resistance in humans.

Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients

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Boden G, Homko C, Mozzoli M, Showe LC, Nichols C, Cheung P. Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients. Diabetes. 2005;54:880-885. Thiazolidinediones (TZDs) are a new class of insulin-sensitizing drugs. To explore how and in which tissues they improve insulin action, we obtained fat and muscle biopsies from eight patients with type 2 diabetes before and 2 months after treatment with rosiglitazone (n = 5) or troglitazone (n = 3).

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Slide Library Results

Search Results for: Adipose tissue Slides Found: 6
Energy Balance: Afferent and Efferent Signals
Energy Balance: Molecules That Regulate Eating and Energy Expenditure
Energy Balance: Molecules That Regulate Eating and Energy Expenditure (cont’d)
Thiazolidinediones and Adipose Tissue Redistribution
Agents That Alter Metabolism
Metabolic and Vascular Actions of PPAR-alpha and PPAR-gamma Agonists