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Advanced glycosylation end-product (AGE)

The nonezymatic glycosylation of protein exposed to hyperglycemic blood for long periods results in formation of AGE. AGEs accumulate over time and induce cross-linking of collagen and other matrix proteins in vascular walls and other tissues. LDLs can then become covalently trapped and accumulate. AGEs in vascular walls may also contribute to thickening, loss of elasticity, and increased permeability of the vascular wall. AGEs stimulate the release of cytokines and induce cell proliferation and inflammatory effects.
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