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Amyloid

Protein deposits seen at autopsy in the pancreatic b-cells of up to 90% of patients with type 2 diabetes.


The following content matched the glossary term: Amyloid

Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an ASCOT substudy

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Stettler C, Witt N, Tapp RJ, et al. Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy.. Diabetes Care. 2009;32(6):1098-1100. To study the association of the inflammatory markers serum amyloid A (SAA) and C-reactive protein (CRP) with retinal microvascular parameters in hypertensive individuals with and without type 2 diabetes.

Evidence for a potent antiinflammatory effect of rosiglitazone

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Mohanty P, Aljada A, Ghanim H, Hofmeyer D, Tripathy D, Syed T, Al-Haddad W, Dhindsa S, Dandona P. Evidence for a potent antiinflammatory effect of rosiglitazone. J Clin Endocrinol Metab. 2004;89:2728-2735. We have recently demonstrated a potent antiinflammatory effect of troglitazone, an agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) and a partial agonist of PPAR-alpha in both the nondiabetic obese and diabetic obese subjects.

β-Cell Dysfunction and Failure in Type 2 Diabetes: Potential Mechanisms

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Porte D Jr, Kahn SE. Beta-Cell Dysfunction and Failure in Type 2 Diabetes: Potential Mechanisms. Diabetes. 2001;50:160-163. Type 2 diabetes is characterized by a progressive loss of β-cell function throughout the course of the disease. The pattern of loss is an initial defect in early or first-phase insulin secretion, followed by a decreasing maximal capacity of glucose to potentiate all nonglucose signals. 

Deficiency of Total and Nonglycosylated Amylin in Plasma Characterizes Subjects With Impaired Glucose Tolerance and Type 2 Diabetes

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Makimattila S, Fineman MS, Yki-Jravinen H. Deficiency of Total and Nonglycosylated Amylin in Plasma Characterizes Subjects With Impaired Glucose Tolerance and Type 2 Diabetes. J Clin Endocrinol Metab. 2000;85:2822-2827. This study was undertaken to characterize first and second phase secretory profiles of total and nonglycosylated amylin and insulin and to determine whether excessive glycosylation of amylin or hyperamylinemia is a feature of abnormal glucose tolerance in humans.

Pancreatic Islet Amyloid: An Important Factor in β-Cell Failure and the Development of Type 2 Diabetes

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Höppener JW, Ahrén B, Lips CJ. Islet amyloid and type 2 diabetes mellitus. N Engl J Med. 2000;343:411-419. 



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Search Results for: Amyloid Slides Found: 2
Role of Islet Amyloid in beta-Cell Dysfunction
Amyloid Deposits in Pancreatic Islets in Type 2 Diabetes