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Beta-cells

A type of cell found in an area of the pancreas called the islets of Langerhans, beta-cells make and release insulin. These cells fail as type 2 diabetes progresses in the body.
The following content matched the glossary term: Beta-cells

Clinical Insights in Diabetes Newsletter October 2013

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Clinical Insights® in Diabetes newsletter October 2013

Exploring DPP-4 CV safety in SAVOR-TIMI 53 and EXAMINE, CV outcomes in Look AHEAD, relationship between gastric bypass and A1C and cardiometabolic risk factors, metabolic effects of bariatric surgery and medical therapy in STAMPEDE, statin use and diabetes risk, severe hypoglycemia and CVD disease risk.

Metabolic effects of bariatric surgery in patients with moderate obesity and type 2 diabetes

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Kashyap SR, Bhatt DL, Wolski, et al. Metabolic effects of bariatric surgery in patients with moderate obesity and type 2 diabetes: analysis of a randomized control trial comparing surgery with intensive medical treatment. Diabetes Care. 2013;36:2175-2182.

Diabetes and cause-specific mortality in a prospective cohort of one million U.S. adults

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Campbell PT, Newton CC, Patel AV, Jacobs EJ, Gapstur SM. Diabetes and cause specific mortality in a prospective cohort of one million U.S. adults. Diabetes Care. 2012 June 14. [Epub ahead of print] Diabetes is a major predictor of death from heart disease and stroke; its impact on nonvascular mortality, including specific cancers, is less understood.

American Diabetes Association 72nd Scientific Sessions Daily Coverage June 10, 2012

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Daily coverage from the American Diabetes Association 72nd Scientific Sessions June 10, 2012

Beta-cell function preservation, ACCORD-BP, update on insulin therapies for diabetes treatment, pharmacology for diabetes prevention, and more. 

Association between diagnosed diabetes and self-reported cancer among u.s. Adults: findings from the 2009 behavioral risk factor surveillance system

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Li C, Balluz LS, Ford ES, Okoro CA, Tsai J, Zhao G. Association between diagnosed diabetes and self-reported cancer among u.s. Adults: findings from the 2009 behavioral risk factor surveillance system. Diabetes Care. 2011;34(6):1365-8. OBJECTIVE To assess the association between diagnosed diabetes and self-reported cancer among U.S. adults.

Overview of the gliptin class (dipeptidyl peptidase-4 inhibitors) in clinical practice

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Bohannon N. Overview of the gliptin class (dipeptidyl peptidase-4 inhibitors) in clinical practice. Postgrad Med. 2009;121(1):40-45. Dipeptidyl peptidase-4 inhibitors (DPP-4s), also commonly called gliptins, are a relatively new class of drugs for the treatment of type 2 diabetes.

Impact of incretin therapy on islet dysfunction: an underlying defect in the pathophysiology of type 2 diabetes

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McGill JB. Impact of incretin therapy on islet dysfunction: an underlying defect in the pathophysiology of type 2 diabetes. Postgrad Med. 2009;121(1):46-58. Glucose homeostasis is governed by a complex interplay of hormonal signaling and modulation. Insulin, glucagon, amylin, the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and other hormones and enzymes interact to maintain glucose homeostasis and normal cellular metabolism. 

The role of incretins in glucose homeostasis and diabetes treatment

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Kim W, Egan JM. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev. Pharmacol Rev. 2008;60(4):470-512. Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within minutes after eating. One of their many physiological roles is to regulate the amount of insulin that is secreted after eating. In this manner, as well as others to be described in this review, their final common raison d'être is to aid in disposal of the products of digestion.

Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes

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Gupta R, Walunj SS, Tokala RK, Parsa KV, Singh SK, Pal M. Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of type 2 diabetes. Curr Drug Targets. 2009;10(1):71-87. Dipeptidyl peptidase IV (DPP IV) is a key regulator of insulin-stimulating hormones, glucagon-like peptide (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), thus it is a promising target for the treatment of Type 2 Diabetes mellitus (T2DM).

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Slide Library Results

Search Results for: Beta-cells Slides Found: 12
Exenatide: Clinical Pharmacology
Effect of GLP-1 on the Beta-Cell
Exenatide: Effect on the Beta-Cell
Beta-Cell Adaptation to Insulin Resistance: Longitudinal Data in Normal Women
Plasticity of Islets: Experimental Increase in Beta-Cell Mass in Response to IR
Neogenesis May Contribute to Increased Islet Mass in Obese Humans
Type 2 Diabetes: Pathogenesis in a Nutshell
Type 2 Diabetes: Pathogenesis in a Nutshell (cont.)
Functional Defects in beta-Cells in the Development of Diabetes
Acute Insulin Response to Glucose
Beta-Cell Mass in Normal Patients and Patients With Diabetes: Autopsy Study
Role of Islet Amyloid in beta-Cell Dysfunction