Click here for slides on this topic


Endothelium

The layer of endothelial cells lining the cavities of the heart and of the blood and lymph systems.


The following content matched the glossary term: Endothelium

Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

Top

Bakker W, Eringa EC, Sipkema P, van Hinsbergh VW. Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity. ACC Abstracts of the 48th Scientific Session. Cell Tissue Res. 2009;335(1):165-189. Endothelial dysfunction comprises a number of functional alterations in the vascular endothelium that are associated with diabetes and cardiovascular disease, including changes in vasoregulation, enhanced generation of reactive oxygen intermediates, inflammatory activation, and altered barrier function.

Effects of rosiglitazone on endothelial function in men with coronary artery disease without diabetes mellitus

Top

Sidhu JS, Cowan D, Kaski JC. Effects of rosiglitazone on endothelial function in men with coronary artery disease without diabetes mellitus. Am J Cardiol. 2004;94:151-156. Recent data have shown that peroxisome proliferator-activated receptor-gamma agonists may exert protective effects on the vascular endothelium by amelioration of insulin resistance and through direct anti-inflammatory effects.

Mechanisms, significance and treatment of vascular dysfunction in type 2 diabetes mellitus : focus on lipid-regulating therapy

Top

Woodman RJ, Chew GT, Watts GF. Mechanisms, significance and treatment of vascular dysfunction in type 2 diabetes mellitus : focus on lipid-regulating therapy. Drugs. 2005;65:31-74. Endothelial dysfunction and increased arterial stiffness occur early in the pathogenesis of diabetic vasculopathy. They are both powerful independent predictors of cardiovascular risk.

Influence of Type 2 Diabetes on Functional and Structural Properties of Coronary Artery Bypass Conduits

Top

Lorusso R, Pentiricci S, Raddino R, et al. Influence of Type 2 Diabetes on Functional and Structural Properties of Coronary Artery Bypass Conduits. Diabetes. 2003;52:2814-2820. Recent studies have reported a high incidence of postoperative unfavorable cardiac-related events in patients with diabetes who underwent coronary artery bypass grafting (CABG). Structural and functional characteristics of CABG conduits, which have been shown to play an important role in patient outcome after myocardial revascularization, have not been fully investigated in diabetic subjects.

Atorvastatin Lowers C-Reactive Protein and Improves Endothelium-Dependent Vasodilation in Type 2 Diabetes Mellitus

Top

K. C. B. Tan, W. S. Chow, S. C. F. Tam, V. H. G. Ai, C. H. L. Lam and K. S. L. Lam. Atorvastatin Lowers C-Reactive Protein and Improves Endothelium-Dependent Vasodilation in Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2002;87:563-568. This study was performed to investigate whether atorvastatin therapy was able to reverse endothelial dysfunction in type 2 diabetes and, if so, whether the effect was due to its antiinflammatory action.

In Persons Without Diabetes, Acute Hyperglycemia Impairs Endothelial Function, Perhaps Through the Production of Oxygen-Derived Free Radicals

Top

Beckman JA, Goldfine AB, Gordon MB, Creager MA. Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans. Circulation. 2001;103:1618-1623. Endothelium-dependent vasodilation is impaired in patients with insulin-dependent and non-insulin-dependent diabetes mellitus and restored by vitamin C administration, implicating a causative role for oxidant stress. Hyperglycemia per se attenuates endothelium-dependent vasodilation in healthy subjects.

Control of Vascular Cell Proliferation and Migration by PPAR-γ

Top

Hsueh WA, Jackson S, Law RE. Control of Vascular Cell Proliferation and Migration by PPAR-y. Diabetes Care. 2001;24:392-397. Compared with nondiabetic subjects, type 2 diabetic individuals are at an increased risk for coronary artery disease and coronary restenosis after angioplasty or stenting.

Nitric Oxide May Be Required to Prevent Hypertension at the Onset of Diabetes

Top

Fitzgerald SM, Brands MW. Nitric Oxide May Be Required to Prevent Hypertension at the Onset of Diabetes. Am J Physiol. 2000;279:E762-E768. Nitric oxide (NO) plays an important role in the regulation of vascular tone, and evidence suggests that endothelial-dependent relaxation, possibly mediated via NO, is impaired in diabetes.

Impaired Endothelium-Dependent Vasodilation in Men With Type 2 Diabetes May Reflect an Abnormality of LDL Quality, Not Quantity

Top

McNeill KL, Fontana L, Russell-Jones DL, et al. Inhibitory effects of low-density lipoproteins from men with type II diabetes on endothelium-dependent relaxation. J Am Coll Cardiol. 2000;35:1622-1627. The object of the present study is to determine whether native (n) low-density lipoprotein (LDL) isolated from men with type II diabetes and abnormal endothelial function inhibits endothelium-dependent relaxation more than n-LDL isolated from nondiabetic control subjects.

Insulin Resistance May Strengthen Likelihood of Early CAD When Angiography Is Negative

Top

Inoue T, Matsunaga R, Sakai Y, Yaguchi I, Takayanagi K, Morooka S. Insulin resistance affects endothelium-dependent acetylcholine-induced coronary artery response. Eur Heart J. 2000;21:895-900. This study was designed to investigate the relationship between insulin resistance and the acetylcholine-induced endothelium-dependent coronary artery response in patients without angiographically significant atherosclerotic coronary artery disease and to elucidate the pathophysiological significance of insulin resistance in the early stages of coronary atherosclerosis.

1 2 Next 

Slide Library Results

Search Results for: Endothelium Slides Found: 0