Click here for slides on this topic


Euglycemic clamp studies

Physiologic studies used to measure insulin resistance in a research setting, Insulin is infused to create matched insulin levels in all subjects. Glucose is infused to maintain matched glucose levels as well. Glucose requirements are used as a measure of insulin sensitivity. Clamps can be performed with isotope-labeled glucose to separately assess the effects of insulin on glucose production and glucose utilization.


The following content matched the glossary term: Euglycemic clamp studies

Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects

Top

Kashyap SR, Roman LJ, Lamont J, et al. Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects. J Clin Endocrinol Metab. 2005;90:1100-1105. Type 2 diabetes is an insulin-resistant state characterized by hyperinsulinemia and accelerated atherosclerosis. In vitro and in vivo studies in rodents have suggested that nitric oxide generation plays an important role in glucose transport and insulin action.

Pioglitazone as monotherapy or in combination with sulfonylurea or metformin enhances insulin sensitivity (HOMA-S or QUICKI)

Top

Tan MH, Glazer NB, Johns D, Widel M, Gilmore KJ. Pioglitazone as monotherapy or in combination with sulfonylurea or metformin enhances insulin sensitivity (HOMA-S or QUICKI) in patients with type 2 diabetes. Curr Med Res Opin. 2004;20:723-728. Miyazaki et al. demonstrated using the hyperinsulinemic, euglycemic clamp that pioglitazone (PIO) enhanced insulin sensitivity in patients (n = 23) with type 2 diabetes (T2D).

Restoration of Adiponectin Pulsatility in Severely Obese Subjects After Weight Loss

Top

Calvani M, Scarfone A, Granato L, Mora EV, Nanni G, Castagneto M, Greco AV, Manco M, Mingrone G. Restoration of Adiponectin Pulsatility in Severely Obese Subjects After Weight Loss. Diabetes. 2004;53:939-947. Diurnal variations of adiponectin levels have been studied in normal-weight men and in diabetic and nondiabetic obese subjects, but no data have been reported in obese subjects after weight loss.

Lipoprotein Lipase Is a Gene for Insulin Resistance in Mexican Americans

Top

Goodarzi MO, Guo X, Taylor KD, et al. Lipoprotein Lipase Is a Gene for Insulin Resistance in Mexican Americans. Diabetes. 2004;53:214-220. The insulin resistance syndrome is increasingly recognized as a risk factor for cardiovascular disease. Lipoprotein lipase (LPL) is a candidate gene for components of the syndrome.

Low Insulin Sensitivity (Si = 0) in Diabetic and Nondiabetic Subjects in the Insulin Resistance Atherosclerosis Study

Top

Haffner SM, D'Agostino R Jr., Festa A, et al. Low Insulin Sensitivity (Si = 0) in Diabetic and Nondiabetic Subjects in the Insulin Resistance Atherosclerosis Study. Is it associated with components of the metabolic syndrome and nontraditional risk factors?. Diabetes Care. 2003;26:2796-2803. To determine the meaning of Si = 0 derived from the frequently sampled intravenous glucose tolerance test.

Vanadyl Sulfate Improves Hepatic and Muscle Insulin Sensitivity in Type 2 Diabetes

Top

K. Cusi, S. Cukier, R. A. DeFronzo, M. Torres, F. M. Puchulu and J. C. Pereira Redondo. Vanadyl Sulfate Improves Hepatic and Muscle Insulin Sensitivity in Type 2 Diabetes. J Clin Endocrinol Metab. 2001;86:1410-1417. Vanadyl sulfate (VOSO4) is an oxidative form of vanadium that in vitro and in animal models of diabetes has been shown to reduce hyperglycemia and insulin resistance. Small clinical studies of 2- to 4-week duration in type 2 diabetes (T2DM) have led to inconsistent results.

Subdivisions of Subcutaneous Abdominal Adipose Tissue and Insulin Resistance

Top

Kelley DE, Leland Thaete F, Troost F, Huwe T, Goodpaster BH. Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am J Physiol. 2000;278:E941-E948. Whereas truncal (central) adiposity is strongly associated with the insulin resistant metabolic syndrome, it is uncertain whether this is accounted for principally by visceral adiposity (VAT). Several recent studies find as strong or stronger association between subcutaneous abdominal adiposity (SAT) and insulin resistance.

Effects of Free Fatty Acids on Glucose Transport and IRS-1–Associated Phosphatidylinositol 3-Kinase Activity

Top

Dresner A, Laurent D, Marcucci M, et al. Effects of Free Fatty Acids on Glucose Transport and IRS-1-Associated Phosphatidylinositol 3-Kinase Activity. J Clin Invest. 1999;103:253-259. To examine the mechanism by which free fatty acids (FFA) induce insulin resistance in human skeletal muscle, glycogen, glucose-6-phosphate, and intracellular glucose concentrations were measured.



Slide Library Results

Search Results for: Euglycemic clamp studies Slides Found: 0