Click here for slides on this topic


Fenofibrate

An oral medication of the fibrate class, it is mainly used with diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and triglycerides (fatty substances) in blood. Like other fibrates, fenofibrate acts on PPAR-alpha to reduce cholesterol levels.


The following content matched the glossary term: Fenofibrate

Effects of intensive glucose lowering in type 2 diabetes

Top

The Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358(24):2545-2559. The Action to Control Cardiovascular Risk in Diabetes (ACCORD) study investigated the effects of intensive glucose-lowering therapy on CV event reduction among patients with type 2 diabetes and either risk factors for, or established, cardiovascular disease.

Fenofibrate-associated changes in renal function and relationship to clinical outcomes among individuals with type 2 diabetes: the ACCORD experience

Top

Bonds DE, Craven TE, Buse J, Crouse JR, Cuddihy R, Elam M, Ginsberg HN, Kirchner K, Marcovina S, Mychaleckyj JC, O'Connor PJ, Sperl-Hillen JA. Fenofibrate associated changes in renal function and relationship to clinical outcomes among individuals with type 2 diabetes the Action to Control Cardiovascular Risk in Diabetes (ACCORD) experience. Diabetologia. 2012 Mar 27. Epub ahead of print. Fenofibrate has been noted to cause an elevation in serum creatinine in some individuals.

Glycemic control over 5 years in 4,900 people with type 2 diabetes: real-world diabetes therapy in a clinical trial cohort

Top

Best JD, Drury PL, Davis TM, Taskinen MR, Kesäniemi YA, Scott R, Pardy C, Voysey M, Keech AC on behalf of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study investigators. Glycemic control over 5 years in 4,900 people with type 2 diabetes real world diabetes therapy in a clinical trial cohort. Diabetes Care. 2012 Mar 19. Epub ahead of print. Glycemic control in type 2 diabetes generally worsens over time, requiring intensification of therapy. The Fenofibrate Intervention and Event Lowering in Diabetes trial provided the opportunity to observe glycemic control in a real-world setting.

Benefits and safety of long-term fenofibrate therapy in people with type 2 diabetes and renal impairment: the FIELD study

Top

Ting RD, Keech AC, Drury PL, Donoghoe MW, Hedley J, Jenkins AJ, Davis TM, Lehto S, Celermajer D, Simes RJ, Rajamani K, Stanton K; on behalf of the FIELD Study Investigators. Benefits and safety of long term fenofibrate therapy in people with type 2 diabetes and renal impairment the FIELD study. Diabetes Care. 2012 Feb;35(2):218-225. OBJECTIVE Diabetic patients with moderate renal impairment are at particular cardiovascular risk.

Effects of combination lipid therapy in type 2 diabetes mellitus

Top

ACCORD Study Group, Ginsberg HN, Elam MB, Lovato LC, et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med. 2010;362(17):1563-1574. We investigated whether combination therapy with a statin plus a fibrate, as compared with statin monotherapy, would reduce the risk of cardiovascular disease in patients with type 2 diabetes mellitus who were at high risk for cardiovascular disease.

The pleiotropic action of short-term metformin and fenofibrate treatment, combined with lifestyle intervention

Top

Pruski M, Krysiak R, Okopien B. The pleiotropic action of short-term metformin and fenofibrate treatment, combined with lifestyle intervention, in type 2 diabetic patients with mixed dyslipidemia. Diabetes Care. 2009 May 12. [Epub ahead of print]. To compare the effect of short-term metformin and fenofibrate treatment, administered alone or in sequence, on glucose and lipid metabolism, cardiovascular risk factors and monocyte cytokine release in type 2 diabetic patients with mixed dyslipidemia.

Pleiotropic action of short-term metformin & fenofibrate treatment, combined w lifestyle intervention, in type 2 diabetic patients w mixed dyslipidemia

Top

Pruski M, Krysiak R, Okopien B. Pleiotropic action of short-term metformin and fenofibrate treatment, combined with lifestyle intervention, in type 2 diabetic patients with mixed dyslipidemia. Diabetes Care. 2009;32(8):1421-1424. To compare the effect of short-term metformin and fenofibrate treatment, administered alone or in sequence, on glucose and lipid metabolism, cardiovascular risk factors, and monocyte cytokine release in type 2 diabetic patients with mixed dyslipidemia.

Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): analysis of a randomised controlled trial

Top

Rajamani K, Colman PG, Li LP, et al for the FIELD study investigators. Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial. Lancet. 2009;373(9677):1780-1788. Amputations in people with type 2 diabetes mellitus substantially impair their quality of life and impose high costs on health-care systems. Our aim was to assess the effect of fenofibrate on amputation events in a large cohort of patients with type 2 diabetes.

Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial

Top

Keech AC, Mitchell P, Summanen PA, et al. Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. Lancet. 2007;370(9600):1687-97. Laser treatment for diabetic retinopathy is often associated with visual field reduction and other ocular side-effects. Our aim was to assess whether long-term lipid-lowering therapy with fenofibrate could reduce the progression of retinopathy and the need for laser treatment in patients with type 2 diabetes mellitus.

Fenofibrate therapy ameliorates fasting and postprandial lipoproteinemia, oxidative stress, and the inflammatory response in subjects

Top

Rosenson RS, Wolff DA, Huskin AL, Helenowski IB, Rademaker AW. Fenofibrate therapy ameliorates fasting and postprandial lipoproteinemia, oxidative stress, and the inflammatory response in subjects with hypertriglyceridemia and the metabolic syndrome. Diabetes Care. 2007 Aug;30(8):1945-51. Epub 2007 May 4. OBJECTIVE: The aim of this study was to determine the effects of fenofibrate (160 mg/day) on fasting and postprandial lipoproteins, oxidized fatty acids, and inflammatory mediators in subjects with hypertriglyceridemia and the metabolic syndrome.

1 2 Next 

Slide Library Results

Search Results for: Fenofibrate Slides Found: 5
Improvement of Lipid Profiles: Morbidity and Mortality Improvement of Lipid Profiles in Patients With Diabetes Reduces Cardiovascular Morbidity and Mortality
ACCORD: Study Design
ACCORD LIPID: Effects of Combination Statin + Fibrate Therapy
ACCORD LIPID: Effects of Combination Statin + Fibrate Therapy
IDF Type 2 Diabetes Guidelines CVD Risk Reduction Treatment | NDEI