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Glucose disposal rate

The rate of glucose uptake from the blood by the peripheral tissues, such as skeletal muscle.


The following content matched the glossary term: Glucose disposal rate

Insulin Resistance Is a Poor Predictor of Type 2 Diabetes in Individuals With no Family History of Disease

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Goldfine AB, Bouche C, Parker RA, et al. Insulin Resistance Is a Poor Predictor of Type 2 Diabetes in Individuals With no Family History of Disease. Proc Natl Acad Sci USA. 2003;100:2724-2729. In normoglycemic offspring of two type 2 diabetic parents, low insulin sensitivity (SI) and low insulin-independent glucose effectiveness (SG) predict the development of diabetes one to two decades later.

Thiazolidinediones Increase Plasma-Adipose Tissue FFA Exchange Capacity and Enhance Insulin-Mediated Control of Systemic FFA Availability

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Oakes ND, Thalen PG, Jacinto SM, Ljung B. Thiazolidinediones Increase Plasma-Adipose Tissue FFA Exchange Capacity and Enhance Insulin-Mediated Control of Systemic FFA Availability. Diabetes. 2001;50:1158-1165. We studied the effects of thiazolidinedione treatment (rosiglitazone 1 or 10 µmol · kg-1 · day-1 or darglitazone 1.3 µmol · kg-1 · day-1 for 3 weeks) on lipid metabolism in obese Zucker rats. In the basal 7-h fasted state, rosiglitazone (10 µmol · kg-1 · day-1) and darglitazone corrected the hypertriglyceridemia by increasing plasma triglyceride (TG) clearance and decreasing hepatic TG production, as assessed using Triton WR 1339.

Vanadyl Sulfate Improves Hepatic and Muscle Insulin Sensitivity in Type 2 Diabetes

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K. Cusi, S. Cukier, R. A. DeFronzo, M. Torres, F. M. Puchulu and J. C. Pereira Redondo. Vanadyl Sulfate Improves Hepatic and Muscle Insulin Sensitivity in Type 2 Diabetes. J Clin Endocrinol Metab. 2001;86:1410-1417. Vanadyl sulfate (VOSO4) is an oxidative form of vanadium that in vitro and in animal models of diabetes has been shown to reduce hyperglycemia and insulin resistance. Small clinical studies of 2- to 4-week duration in type 2 diabetes (T2DM) have led to inconsistent results.

Peroxisome Proliferator–Activated Receptor (PPAR)-Ã??± Activation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat–Fed Rats

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Ye J-M, Doyle PJ, Iglesias MA, Watson DG, Cooney GJ, Kraegan EW. Peroxisome Profliferator-Activated Receptor (PPAR)-Alpha Activation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat-Fed Rats. Diabetes. 2001;50:411-417. Peroxisome proliferator-activated receptor (PPAR)-Ã??± agonists lower circulating lipids, but the consequences for muscle lipid metabolism and insulin sensitivity are not clear.

Glucose Turnover and Adipose Tissue Lipolysis Are Insulin-Resistant in Healthy Relatives of Type 2 Diabetes Patients

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Eriksson JW, Smith U, Waagstein F, Wysocki M, Jansson PA. Glucose Turnover and Adipose Tissue Lipolysis Are Insulin-Resistant in Healthy Relatives of Type 2 Diabetes Patients. Is Cellular Insulin Resistance a Secondary Phenomenon? Diabetes. 1999;48:1572-1578. To elucidate potential mechanisms for insulin resistance occurring early in the development of type 2 diabetes, we studied 10 young healthy individuals, each with two first-degree relatives with type 2 diabetes, and 10 control subjects without known type 2 diabetic relatives.

Restoration of Early Rise in Plasma Insulin Levels Improves the Glucose Tolerance of Type 2 Diabetic Patients

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Bruttomesso D, Pianta A, Mari A, Valerio A, Marescotti MC, Avogaro A, Tiengo A, Del Prato S. Restoration of early rise in plasma insulin levels improves the glucose tolerance of type 2 diabetic patients. Diabetes. 1999;48(1):99-105. The loss of first-phase insulin secretion is a characteristic feature of type 2 diabetic patients. The fast-acting insulin analog lispro provides a therapeutic tool for assessing the metabolic outcome of restoration of an early rise in plasma insulin levels after the ingestion of an oral glucose load.

Insulin Sensitivity, Insulin Action, and Fibrinolysis Activity in Nondiabetic and Diabetic Obese Subjects

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Fendri S, Roussel B, Lormeau B, et al. Insulin Sensitivity, Insulin Action, and Fibrinolysis Activity in Nondiabetic and Diabetic Obese Subjects  Metabolism. 1998;47:1372-1375. Because inconsistencies occur with regard to the relative contribution of insulin to the hypofibrinolysis characteristic of obesity and diabetes, we explored the relationship between insulin and fibrinolysis, assessing both insulin sensitivity and insulin action.

Metabolic Effects of Troglitazone Monotherapy in Type 2 Diabetes Mellitus

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Maggs DG, Buchanan TA, Burant CF, et al. Metabolic Effects of Troglitazone Monotherapy in Type 2 Diabetes Mellitus. Ann Intern Med. 1998;128:176-185. To determine the effects of 6 months of troglitazone monotherapy on glucose metabolism in patients with type 2 diabetes mellitus.

TNF-a-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone

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Miles PDG, Romeo OM, Higo K, Cohen A, Rafaat K, Olefsky JM. Diabetes TNF-a-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone Diabetes. 1997;46:1678-1683. Tumor necrosis factor (TNF)-a may play a role in the insulin resistance of obesity and NIDDM. Troglitazone is a new orally active hypoglycemic agent that has been shown to ameliorate insulin resistance and hyperinsulinemia in both diabetic animal models and NIDDM subjects.



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