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Glycogen

A polysaccharide made up of multiple units of glucose. It is the major storage form of carbohydrate in animals and is found primarily in the liver, kidney and muscle. When needed, glycogen is broken down to glucose, which can be released from liver and kidney (but not muscle) into the circulation.


The following content matched the glossary term: Glycogen

Interleukin-6 Induces Cellular Insulin Resistance in Hepatocytes

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Senn JJ, Klover PJ, Nowak IA, Mooney RA. Interleukin-6 Induces Cellular Insulin Resistance in Hepatocytes. Diabetes. 2002;51:3391-3399. Interleukin (IL)-6 is one of several proinflammatory cytokines that have been associated with insulin resistance and type 2 diabetes. A two- to threefold elevation of circulating IL-6 has been observed in these conditions. Nonetheless, little evidence supports a direct role for IL-6 in mediating insulin resistance.

Effects of Tungstate, a New Potential Oral Antidiabetic Agent, in Zucker Diabetic Fatty Rats

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Munoz MC, Barbera A, Dominguez J, et al. Effects of Tungstate, a New Potential Oral Antidiabetic Agent, in Zucker Diabetic Fatty Rats. Diabetes. 2001;50:131-138.Tungstate was orally administered to 7.5-week-old male Zucker diabetic fatty (ZDF) rats that already showed moderate hyperglycemia.

Failure of Blood Glucagon Levels to Fall After a Meal Contributes to Postprandial Hyperglycemia in Type 2 Diabetes

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Shah P, Vella A, Basu A, et al. Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2000;85:4053-4059. We tested the hypothesis that a lack of suppression of glucagon causes postprandial hyperglycemia in subjects with type 2 diabetes.

Effects of High-Fat Diet and Exercise Training on Intracellular Glucose Metabolism in Rats

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Kim C-H, Youn JH, Park J-Y, et al. Effects of High-Fat Diet and Exercise Training on Intracellular Glucose Metabolism in Rats. Am J Physiol. 2000;278:E977-E984. We examined the effects of high-fat diet (HFD) and exercise training on insulin-stimulated whole body glucose fluxes and several key steps of glucose metabolism in skeletal muscle.

Effects of Troglitazone on Substrate Storage and Utilization in Insulin-Resistant Rats

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Sreenan S, Keck S, Fuller T, Cockburn B, Burant CF. Effects of Troglitazone on Substrate Storage and Utilization in Insulin-Resistant Rats. Am J Physiol. 1999;276:1119-1129. Elevated serum and tissue lipid stores are associated with skeletal muscle insulin resistance and diminished glucose-stimulated insulin secretion, the hallmarks of type 2 diabetes.

Effect of Chronic Treatment With Lacidipine or Lisinopril on Intracellular Partitioning of Glucose Metabolism in Type 2 Diabetes Mellitus

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Bonora E, Targher G, Alberiche M. Effect of Chronic Treatment With Lacidipine or Lisinopril on Intracellular Partitioning of Glucose Metabolism in Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 1999;84:1544-1550. Antihypertensive treatment is frequently needed in type 2 diabetes.

Effects of Free Fatty Acids on Glucose Transport and IRS-1–Associated Phosphatidylinositol 3-Kinase Activity

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Dresner A, Laurent D, Marcucci M, et al. Effects of Free Fatty Acids on Glucose Transport and IRS-1-Associated Phosphatidylinositol 3-Kinase Activity. J Clin Invest. 1999;103:253-259. To examine the mechanism by which free fatty acids (FFA) induce insulin resistance in human skeletal muscle, glycogen, glucose-6-phosphate, and intracellular glucose concentrations were measured.



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Diurnal Pattern to Insulin Action in Type 1 Diabetes: Design