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Hyperinsulinemia

Elevated blood levels of insulin. Since insulin levels are distributed in the population in a continuous fashion, there is no widely agreed upon definition of hyperinsulinemia.


The following content matched the glossary term: Hyperinsulinemia

Prevalence of pre-diabetes, association with cardiometabolic risk factors and hyperinsulinemia among US adolescents: NHANES 2005-2006

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Li C, Ford ES, Zhao G, Mokdad AH. Prevalence of pre-diabetes and its association with clustering of cardiometabolic risk factors and hyperinsulinemia among U.S. adolescents: National Health and Nutrition Examination Survey 2005-2006. Diabetes Care. 2009;32(2):342-347. Impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) are considered to constitute "pre-diabetes." We estimated the prevalence of IFG, IGT, and pre-diabetes among U.S. adolescents using data from a nationally representative sample.

Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

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Bakker W, Eringa EC, Sipkema P, van Hinsbergh VW. Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity. ACC Abstracts of the 48th Scientific Session. Cell Tissue Res. 2009;335(1):165-189. Endothelial dysfunction comprises a number of functional alterations in the vascular endothelium that are associated with diabetes and cardiovascular disease, including changes in vasoregulation, enhanced generation of reactive oxygen intermediates, inflammatory activation, and altered barrier function.

Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects

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Kashyap SR, Roman LJ, Lamont J, et al. Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects. J Clin Endocrinol Metab. 2005;90:1100-1105. Type 2 diabetes is an insulin-resistant state characterized by hyperinsulinemia and accelerated atherosclerosis. In vitro and in vivo studies in rodents have suggested that nitric oxide generation plays an important role in glucose transport and insulin action.

Diabetes, glucose, insulin, and heart rate variability: The Atherosclerosis Risk in Communities (ARIC) study

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Schroeder EB, Chambless LE, Liao D, et al. Diabetes, Glucose, Insulin, and Heart Rate Variability: The Atherosclerosis Risk in Communities (ARIC) study. Diabetes Care. 2005;28:668-674. OBJECTIVE: To describe the progression of autonomic impairment among individuals with diabetes and pre-diabetic metabolic impairments.

Heritability of Multivariate Factors of the Metabolic Syndrome in Nondiabetic Japanese Americans

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Austin MA, Edwards KL, McNeely MJ, Chandler WL, Leonetti DL, Talmud PJ, Humphries SE, Fujimoto WY. Heritability of Multivariate Factors of the Metabolic Syndrome in Nondiabetic Japanese Americans. Diabetes. 2004;53:1166-1169. A rapidly growing body of evidence demonstrates important associations between the metabolic syndrome, characterized by a cluster of risk factors or phenotypes that include dyslipidemia, central obesity, hypertension, and hyperinsulinemia, and both cardiovascular disease and type 2 diabetes.

Enhanced Fat Oxidation Through Physical Activity Is Associated With Improvements in Insulin Sensitivity in Obesity

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Goodpaster BH, Katsiaras A, Kelley DE. Enhanced Fat Oxidation Through Physical Activity Is Associated With Improvements in Insulin Sensitivity in Obesity. Diabetes. 2003;52:2191-2197. Skeletal muscle insulin resistance entails dysregulation of both glucose and fatty acid metabolism. This study examined whether a combined intervention of physical activity and weight loss influences fasting rates of fat oxidation and insulin-stimulated glucose disposal.

Antiatherogenic Effect of Pioglitazone in Type 2 Diabetic Patients Irrespective of the Responsiveness to Its Antidiabetic Effect

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Satoh N, Ogawa Y, Usui T, Tagami T, Kono S, Uesugi H, et al. Antiatherogenic Effect of Pioglitazone in Type 2 Diabetic Patients Irrespective of the Responsiveness to Its Antidiabetic Effect. Diabetes Care. 2003;26:2588-2594. This study was designed to elucidate the relationship between the antiatherogenic and antidiabetic effects of pioglitazone, a TZD, in type 2 diabetic patients.

Effects of Metformin and Rosiglitazone Monotherapy on Insulin-Mediated Hepatic Glucose Uptake and Their Relation to Visceral Fat in Type 2 Diabetes

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Iozzo P, Hallsten K, Oikonen V, et al. ;Effects of Metformin and Rosiglitazone Monotherapy on Insulin-Mediated Hepatic Glucose Uptake and Their Relation to Visceral Fat in Type 2 Diabetes. Diabetes Care. 2003;26:2069-2074. Impaired insulin-mediated hepatic glucose uptake (HGU) has been implicated in the hyperglycemia of type 2 diabetes.

Weight Loss-Induced Plasticity of Glucose Transport and Phosphorylation in the Insulin Resistance of Obesity and Type 2 Diabetes

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Williams KV, Bertoldo A, Kinahan P, Cobelli C, Kelley DE. Weight loss-induced plasticity of glucose transport and phosphorylation in the insulin resistance of obesity and type 2 diabetes. Diabetes. 2003;52:1619-1626. We tested the hypothesis that weight loss alleviates insulin resistance in skeletal muscle within the proximal steps of glucose metabolism, namely substrate delivery, glucose transport, and glucose phosphorylation.

Arterial Stiffness Increases With Deteriorating Glucose Tolerance Status: The Hoorn Study

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Henry RMA, Kostense PJ, Spijkerman AMW, et al. Arterial Stiffness Increases With Deteriorating Glucose Tolerance Status: The Hoorn Study. Circulation. 2003;107:2089-2095. Type 2 diabetes (DM-2) and impaired glucose metabolism (IGM) are associated with an increased cardiovascular disease risk.

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Search Results for: Hyperinsulinemia Slides Found: 6
Prevalence of the Insulin Resistance Syndrome (NCEP) in the US Population
Homozygous Mutation in Melanocortin-4 Receptor Gene
Increased Fructose Consumption and the Rise in Obesity
Association Between Hyperinsulinemia and Low HDL-C
Prevalence of IFG, IGT, and Prediabetes by Cardiometabolic Risk Factors
Prevalence of IFG, IGT, and Prediabetes According to a Combination of Central Obesity and Hyperinsulinemia