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Oxidative stress

The stress associated with defense against elevated and prolonged exposure to chemical species capable of an oxidizing reaction. The factorial design of ORIGIN allowed for investigation of two interventions in a single study. Via two arms, the study investigated whether insulin replacement therapy with insulin glargine targeting fasting normoglycemia (FPG ≤95 mg/dL) reduces
The following content matched the glossary term: Oxidative stress

Clinical Insights in Diabetes Newsletter Archive

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Clinical Insights® in Diabetes Newsletter Archive

Antioxidant and anti-inflammatory effects of exercise in diabetic patients

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Golbidi S, Badran M, Laher I. Antioxidant and anti-inflammatory effects of exercise in diabetic patients. Exp Diabetes Res. 2012; 2012: 941868. This paper briefly reviews the pathophysiological pathways associated with oxidative stress and inflammation in diabetes mellitus and then discusses the impact of exercise on these systems.

Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents

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Kohnert KD, Augstein P, Zander E, et al. Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents. Diabetes Care. 2009;32(6):1058-1062. Glucose fluctuations trigger activation of oxidative stress, a main mechanism leading to secondary diabetes complications. We evaluated the relationship between glycemic variability and beta-cell dysfunction.

Fenofibrate therapy ameliorates fasting and postprandial lipoproteinemia, oxidative stress, and the inflammatory response in subjects

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Rosenson RS, Wolff DA, Huskin AL, Helenowski IB, Rademaker AW. Fenofibrate therapy ameliorates fasting and postprandial lipoproteinemia, oxidative stress, and the inflammatory response in subjects with hypertriglyceridemia and the metabolic syndrome. Diabetes Care. 2007 Aug;30(8):1945-51. Epub 2007 May 4. OBJECTIVE: The aim of this study was to determine the effects of fenofibrate (160 mg/day) on fasting and postprandial lipoproteins, oxidized fatty acids, and inflammatory mediators in subjects with hypertriglyceridemia and the metabolic syndrome.

Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes

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Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006;295:1681-1687. OBJECTIVE: To assess the respective contributions of sustained chronic hyperglycemia and of acute glucose fluctuations to oxidative stress in type 2 diabetes.

Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

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Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J Biol Chem. 2004 Jul 16 [Epub ahead of print]. Glucose in chronic excess causes toxic effects on structure and function of organs, including the pancreatic islet.

Nitric Oxide, Oxidative Excess, and Vascular Complications of Diabetes Mellitus

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Endemann DH, Schiffrin EL. Nitric Oxide, Oxidative Excess, and Vascular Complications of Diabetes Mellitus. Curr Hypertens Rep. 2004;6:85-89. The prevalence of diabetes mellitus is rising worldwide and has reached epidemic dimensions. Diabetes mellitus places patients at high cardiovascular risk.

Mechanisms, significance and treatment of vascular dysfunction in type 2 diabetes mellitus : focus on lipid-regulating therapy

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Woodman RJ, Chew GT, Watts GF. Mechanisms, significance and treatment of vascular dysfunction in type 2 diabetes mellitus : focus on lipid-regulating therapy. Drugs. 2005;65:31-74. Endothelial dysfunction and increased arterial stiffness occur early in the pathogenesis of diabetic vasculopathy. They are both powerful independent predictors of cardiovascular risk.

New aspects in the pathogenesis of diabetic atherothrombosis

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Moreno PR, Fuster V. New aspects in the pathogenesis of diabetic atherothrombosis. J Am Coll Cardiol. 2004;44:2293-2300. Diabetes mellitus is increasing worldwide, resulting from the interaction of obesity, inflammation, and hyperglycemia.

Hyperlipidemia Is Toxic to b-Cells, but Only in the Presence of Hyperglycemia

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Poitout V, Robertson RP. Minireview: Secondary Beta-Cell Failure in Type 2 Diabetes-A Convergence of Glucotoxicity and Lipotoxicity. Endocrinology. 2002;143:339-342. Both hyperglycemia and hyperlipidemia have been implicated as contributors to b-cell failure in type 2 diabetes. The authors of a recent review article believe that chronic hyperglycemia, by itself, is toxic to b-cells, whereas chronic hyperlipidemia is only toxic to beta-cells in the presence of hyperglycemia.

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Search Results for: Oxidative stress Slides Found: 2
POPADAD Trial: Effect of Antioxidant Use on Events in Patients With Diabetes
Diabetes Cognitive Dysfunction | NDEI