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Plasminogen activator inhibitor (PAI) type 1

An endothelial derived protein in blood that inhibits conversion of plasminogen to plasmin by inhibiting plasminogen activator. The inhibition limits clot propagation.


The following content matched the glossary term: Plasminogen activator inhibitor (PAI) type 1

Pleiotropic action of short-term metformin & fenofibrate treatment, combined w lifestyle intervention, in type 2 diabetic patients w mixed dyslipidemia

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Pruski M, Krysiak R, Okopien B. Pleiotropic action of short-term metformin and fenofibrate treatment, combined with lifestyle intervention, in type 2 diabetic patients with mixed dyslipidemia. Diabetes Care. 2009;32(8):1421-1424. To compare the effect of short-term metformin and fenofibrate treatment, administered alone or in sequence, on glucose and lipid metabolism, cardiovascular risk factors, and monocyte cytokine release in type 2 diabetic patients with mixed dyslipidemia.

Low Insulin Sensitivity (Si = 0) in Diabetic and Nondiabetic Subjects in the Insulin Resistance Atherosclerosis Study

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Haffner SM, D'Agostino R Jr., Festa A, et al. Low Insulin Sensitivity (Si = 0) in Diabetic and Nondiabetic Subjects in the Insulin Resistance Atherosclerosis Study. Is it associated with components of the metabolic syndrome and nontraditional risk factors?. Diabetes Care. 2003;26:2796-2803. To determine the meaning of Si = 0 derived from the frequently sampled intravenous glucose tolerance test.

Lifestyle Modification Improves Endothelial Function in Obese Subjects With the Insulin Resistance Syndrome

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Hamdy O, Ledbury S, Mullooly C, et al. Lifestyle Modification Improves Endothelial Function in Obese Subjects With the Insulin Resistance Syndrome. Diabetes Care. 2003;26:2119-2125. Endothelial dysfunction has been reported in type 2 diabetic patients and in obese subjects with insulin resistance syndrome (IRS). This study evaluates the effects of weight reduction and exercise on vascular reactivity of the macro- and microcirculation in obese subjects with IRS.

Suppression of Nuclear Factor-kappaB and Stimulation of Inhibitor kappaB by Troglitazone

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Ghanim H, Garg R, Aljada A, et al. Suppression of Nuclear Factor-B and Stimulation of Inhibitor B by Troglitazone: Evidence for an Anti-inflammatory Effect and a Potential Antiatherosclerotic Effect in the Obese. Endocrinology. 2001;86:1306-1312. To elucidate whether troglitazone exerts an antiinflammatory effect in humans, in vivo, we investigated the suppression of nuclear factor kappaB (NFkappaB) in mononuclear cells (MNC) by this drug.

Increased Plasminogen Activator Inhibitor-1 Activity in Offspring of Type 2 Diabetic Patients

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Gurlek A, Bayraktar M, Kirazli S. Increased Plasminogen Activator Inhibitor-1 Activity in Offspring of Type 2 Diabetic Patients: Lack of Association With Plasma Insulin Levels. Diabetes Care. 2000;23:88-92. To determine whether a dysregulation of the fibrinolytic system exists in normal glucose-tolerant offspring of type 2 diabetic patients.

Insulin Sensitivity in Subjects With Type 2 Diabetes Relationship to Cardiovascular Risk Factors: The Insulin Resistance Atherosclerosis Study

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Haffner SM, D"Agostino R Jr, Mykkänen L, et al. Insulin Sensitivity in Subjects With Type 2 Diabetes Relationship to Cardiovascular Risk Factors: The Insulin Resistance Atherosclerosis Study. Diabetes Care. 1999;22:562-568. Among nondiabetic subjects, insulin resistance has been associated with increased cardiovascular risk factors, including dyslipidemia, hypertension, impaired fibrinolysis, and coagulation. Less is known about the relationship between insulin resistance and cardiovascular risk factors in subjects with type 2 diabetes.

Insulin Sensitivity, Insulin Action, and Fibrinolysis Activity in Nondiabetic and Diabetic Obese Subjects

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Fendri S, Roussel B, Lormeau B, et al. Insulin Sensitivity, Insulin Action, and Fibrinolysis Activity in Nondiabetic and Diabetic Obese Subjects  Metabolism. 1998;47:1372-1375. Because inconsistencies occur with regard to the relative contribution of insulin to the hypofibrinolysis characteristic of obesity and diabetes, we explored the relationship between insulin and fibrinolysis, assessing both insulin sensitivity and insulin action.

Troglitazone Improves Defects in Insulin Action, Insulin Secretion, Ovarian Steroidogenesis, and Fibrinolysis in Women With Polycystic Ovary Syndrome

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Ehrmann DA, Schneider DJ, Sobel BE, et al. Troglitazone Improves Defects in Insulin Action, Insulin Secretion, Ovarian Steroidogenesis, and Fibrinolysis in Women With Polycystic Ovary Syndrome.  J Clin Endocrinol Metab. 1997;82:2108-2116. Women with polycystic ovary syndrome (PCOS)are characterized by defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis. We administered the insulin-sensitizing agent troglitazone to 13 obese women with PCOS and impaired glucose tolerance to determine whether attenuation of hyperinsulinemia ameliorates these defects.



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