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Renin

An enzyme produced by the kidney that is involved in the regulation of blood pressure. Renin converts angiotensinogen to angiotensin I, the precursor of the potent vasoconstrictor angiotensin II.


The following content matched the glossary term: Renin

Prevention of diabetes & cardiovascular disease in patients w/ impaired glucose tolerance: rationale & design of Nateglinide & Valsartan

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Califf RM, Boolell M, Haffner SM, Bethel MA, McMurray J, Duggal A, Holman RR; NAVIGATOR Study Group. Prevention of diabetes and cardiovascular disease in patients with impaired glucose tolerance: rationale and design of the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial. Am Heart J. 2008;156(4):623-632. Patients with impaired glucose tolerance (IGT) have increased risk for developing type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Lifestyle modification and medication can prevent or delay progression to diabetes (PD), but whether such interventions also reduce the risk of CVD has not been rigorously tested.

Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease

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Kunz R, Friedrich C, Wolbers M, Mann JF. Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease. Arch Intern Med. 2008;148(1):30-48.

The role of the renin-angiotensin-aldosterone system in diabetes and its vascular complications

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Cooper ME. The role of the renin-angiotensin-aldosterone system in diabetes and its vascular complications. Am J Hypertension.. 2004;17:16S-20S. Clinical trials have demonstrated the benefit of blood pressure (BP) reduction in reducing the risk of cardiovascular and renal complications in patients with diabetes mellitus.

Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy

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de Zeeuw D, Remuzzi G, Parving HH, et al. Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy. Circulation. 2004;110(8):921-927. Albuminuria is an established risk marker for both cardiovascular and renal outcomes.

Diabetes mellitus, the renin-angiotensin-aldosterone system, and the heart

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Lim HS, MacFadyen RJ, Lip GY. Diabetes mellitus, the renin-angiotensin-aldosterone system, and the heart. Arch Intern Med. 2004;164:1737-1748. With diabetes mellitus reaching epidemic proportions, mainly secondary to obesity, the impact of cardiovascular disease due to this combination makes it a dominant public health problem during the first quarter of the 21st century.

The Tissue Renin-Angiotensin-Aldosterone System in Diabetes Mellitus

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Hanes DS, Nahar A, Weir MR. The Tissue Renin-Angiotensin-Aldosterone System in Diabetes Mellitus. Curr Hypertens Rep. 2004;6:98-105. Diabetes is associated with an inordinate burden of cardiovascular and renal disease, which is expected to accelerate during the next few decades. The relationship between the renin-angiotensin system (RAS) and diabetic macrovascular and microvascular disease is well established.

Mechanisms, significance and treatment of vascular dysfunction in type 2 diabetes mellitus : focus on lipid-regulating therapy

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Woodman RJ, Chew GT, Watts GF. Mechanisms, significance and treatment of vascular dysfunction in type 2 diabetes mellitus : focus on lipid-regulating therapy. Drugs. 2005;65:31-74. Endothelial dysfunction and increased arterial stiffness occur early in the pathogenesis of diabetic vasculopathy. They are both powerful independent predictors of cardiovascular risk.

Rosiglitazone Improves Insulin Sensitivity and Lowers Blood Pressure in Hypertensive Patients

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Raji A, Seely EW, Bekins SA, Williams GH, Simonson DC. Rosiglitazone Improves Insulin Sensitivity and Lowers Blood Pressure in Hypertensive Patients. Diabetes Care. 2003. 26:172-178. To examine the effect of rosiglitazone on insulin resistance and blood pressure in patients with essential hypertension, classified based on abnormalities of their renin-angiotensin system.

Nitric Oxide May Be Required to Prevent Hypertension at the Onset of Diabetes

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Fitzgerald SM, Brands MW. Nitric Oxide May Be Required to Prevent Hypertension at the Onset of Diabetes. Am J Physiol. 2000;279:E762-E768. Nitric oxide (NO) plays an important role in the regulation of vascular tone, and evidence suggests that endothelial-dependent relaxation, possibly mediated via NO, is impaired in diabetes.

Relationship Between Insulin Resistance and Nonmodulating Hypertension Linkage of Metabolic Abnormalities and Cardiovascular Risk

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Ferri C, Bellini C, Desideri G, et al. Relationship Between Insulin Resistance and Nonmodulating Hypertension Linkage of Metabolic Abnormalities and Cardiovascular Risk. Diabetes. 1999;48:1623-1630. Insulin resistance is a feature common to patients with diabetes and to some with hypertension. It is assumed that this feature confers the increased metabolic risk in hypertension. However, the state of the renin-angiotensin system might contribute to cardiovascular risk, although there is no clear mechanistic explanation.



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Search Results for: Renin Slides Found: 10
CALM: Renoprotection With Candesartan vs Lisinopril in Type 2 Diabetes
Steno-2: Percentage of Patients at Treatment Goals at End of Study
ESH/ESC Hypertension Guidelines: Hypertension Treatment Options
ESH/ESC Hypertension Guidelines: Hypertension Treatment for Women
ESH/ESC Hypertension Guidelines: Hypertension Treatment for People With Diabetes
ESH/ESC Hypertension Guidelines: Hypertension Treatment for People With Metabolic Syndrome
nbESH/ESC Hypertension Guidelines: Hypertension Treatment for Patients With Nephropathy
ALTITUDE: No Reduction in CV, Renal Events with Aliskiren
ALTITUDE: Increased Hyperkalemia, Renal Impairment with Aliskiren
JNC 8 Guidelines Treatment Hypertension CKD PPT | NDEI