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Repaglinide

An oral antihyperglycemic agent of the meglitidine class that is indicated as an adjunct to diet and exercise to lower blood glucose levels in patients with type 2 diabetes whose hyperglycemia cannot be controlled by diet and exercise alone.
The following content matched the glossary term: Repaglinide

CompanionSetType2DiabetesMedications

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Patient education companion set featuring handouts on DPP-4 inhibitors, GLP-1 receptor agonists, SGLT2 inhibitors, and medications used to treat type 2 diabetes (English and Spanish)

Medications Used To Treat Type 2 Diabetes

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Patient education handout showing medications used to treat type 2 diabetes and where and how these medications work in the body to lower blood glucose.

Medicamentos para el tratamiento de la diabetes tipo 2

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Patient education handout showing medications used to treat type 2 diabetes and where and how these medications work in the body to lower blood glucose—in Spanish.

ADA 2016 Type 2 Diabetes Pharmacologic Therapy

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Pharmacologic treatment options for type 2 diabetes from the 2016 ADA guidelines

American Diabetes Association (ADA) Nutrition Guidelines for Adults With Diabetes

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Diabetes management guidelines for nutrition from the American Diabetes Association (ADA)

ADA/European Association for the Study of Diabetes (EASD) Position Statement on Hyperglycemia Management in Type 2 Diabetes

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Joint position statement from ADA/EASD with clinical practice recommendations for managing hyperglycemia in type 2 diabetes

Hypoglycaemia with oral antidiabetic drugs: results from prescription-event monitoring cohorts of rosiglitazone, pioglitazone, nateglinide and repaglinide

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Vlckova V, Cornelius V, Kasliwal R, Wilton L, Shakir SA. Hypoglycaemia with oral antidiabetic drugs: results from prescription-event monitoring cohorts of rosiglitazone, pioglitazone, nateglinide and repaglinide. ACC Abstracts of the 48th Scientific Session. 2009;32(5):409-418. Hypoglycaemia is an acute complication associated with intensive treatment of patients with diabetes mellitus. This complication poses a major challenge in diabetes management. 

Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus

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Esposito K, Giugliano D, Nappo F, Marfella R. Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus. Circulation. 2004;110:214-219. Postprandial hyperglycemia may be a risk factor for cardiovascular disease. We compared the effects of two insulin secretagogues, repaglinide and glyburide, known to have different efficacy on postprandial hyperglycemia, on carotid intima-media thickness (CIMT) and markers of systemic vascular inflammation in type 2 diabetic patients.

Review of Prandial Glucose Regulation With Repaglinide: A Solution to the Problem of Hypoglycaemia in the Treatment of Type 2 Diabetes?

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Nattras M, Lauritzen T. Review of Prandial Glucose Regulation With Repaglinide: A Solution to the Problem of Hypoglycaemia in the Treatment of Type 2 Diabetes?. Int J Obesity. 2000;24(suppl 3):S21-S31. Type 2 diabetes mellitus is characterised by abnormal beta-cell function (present at the time of diagnosis) that is often associated with insulin resistance. An important and consistent pathophysiological finding is the failure to produce adequate increments in insulin secretion in response to carbohydrate intake.

A Double-Blind Randomized Comparison of Meal-Related Glycemic Control by Repaglinide and Glyburide in Well-Controlled Type 2 Diabetic Patients

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Damsbo P, Clauson P, Marbury TC, Windfeld K. A Double-Blind Randomized Comparison of Meal-Related Glycemic Control by Repaglinide and Glyburide in Well-Controlled Type 2 Diabetic Patients. Diabetes Care. 1999;22:789-794. This study was designed to compare diurnal blood glucose excursions and the effects of accidental dietary noncompliance in type 2 diabetic patients who are well-controlled on either repaglinide or glyburide treatment.

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Effects of Antidiabetic Agents on Weight