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Vascular smooth muscle cell

Type of smooth muscle found within and composing the majority of the wall of blood vessels.
The following content matched the glossary term: Vascular smooth muscle cell

Pioglitazone inhibits MMP-1 expression in vascular smooth muscle cells through a mitogen-activated protein kinase-independent mechanism

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Game BA, Maldonado A, He L, Huang Y. Pioglitazone inhibits MMP-1 expression in vascular smooth muscle cells through a mitogen-activated protein kinase-independent mechanism. Atherosclerosis. 2005;178:249-256. Antidiabetic drug thiazolidinedione (TZD) also has anti-atherogenic effects. Among these effects, inhibition of smooth muscle cell (SMC) migration is considered to be essential. However, the mechanism whereby TZD inhibits SMC migration is not well understood.

Pioglitazone May Find a Role in Reducing Restenosis After Arterial Interventions

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Aizawa Y, Kawabe J-I, Hasebe N, et al. Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasia. Circulation. 2001;104:455-460. Cytokines induce apoptosis in vascular disease lesions through enhancement of inducible nitric oxide (NO) synthase (iNOS) activation. The thiazolidinediones, novel insulin-sensitizing agents, have been demonstrated to modulate cytokine-induced NO production.

Control of Vascular Cell Proliferation and Migration by PPAR-γ

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Hsueh WA, Jackson S, Law RE. Control of Vascular Cell Proliferation and Migration by PPAR-y. Diabetes Care. 2001;24:392-397. Compared with nondiabetic subjects, type 2 diabetic individuals are at an increased risk for coronary artery disease and coronary restenosis after angioplasty or stenting.

Influence of LDL Subfraction Profile and LDL Oxidation on Endothelium-Dependent and Independent Vasodilation in Patients With Type 2 Diabetes

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Tan KCB, Ai VHG, Chow WS, Chau MT, Leong L, Lam KSL. Influence of Low Density Lipoprotein (LDL) Subfraction Profile and LDL Oxidation on Endothelium-Dependent and Independent Vasodilation in Patients With Type 2 Diabetes. J Clin Endocrin Metab. 1999;84:3212-3216. Recent studies have suggested that hypercholesterolemia is associated with endothelial dysfunction. In patients with type 2 diabetes mellitus, dyslipidemia is mainly characterized by hypertriglyceridemia, low high density lipoprotein, and a preponderance of small dense low density lipoprotein (LDL) particles. 



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