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Association of weight status with mortality in adults with incident diabetes

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Carnethon MR, De Chavez PJ, Biggs ML, et al. Association of weight status with mortality in adults with incident diabetes. JAMA. 2012;308(6):581-590. Carnethon and colleagues analyzed data from five clinical trials to compare mortality rates among subjects who were normal weight with subjects who were overweight/obese at the time of incident adult-onset diabetes.

Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults

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Neeland IJ, Turer AT, Ayers CR, Powell Wiley TM, Vega GL, Farzaneh Far R, Grundy SM, Khera A, McGuire DK, de Lemos JA. Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults. JAMA. 2012;308(11):1150-1159. The risk of type 2 diabetes mellitus is heterogeneous among obese individuals. Factors that discriminate prediabetes or diabetes risk within this population have not been well characterized.

Impaired Glucose Tolerance and Obesity as Effect Modifiers of Ethnic Disparities of the Progression to Diabetes: The San Antonio Heart Study

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Lorenzo C, Lee R, Haffner SM. Impaired Glucose Tolerance and Obesity as Effect Modifiers of Ethnic Disparities of the Progression to Diabetes: The San Antonio Heart Study. Diabetes Care. 2012 Aug 24. Epub ahead of print. The Diabetes Prevention Program (DPP) reported no racial/ethnic differences in the incidence of diabetes in individuals with impaired glucose tolerance (IGT). Therefore, it has been hypothesized that factors associated with racial/ethnic disparities act prior to the development of IGT.

Ethnic Differences in Weight Loss and Diabetes Remission After Bariatric Surgery: A meta-analysis

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Admiraal WM, Celik F, Gerdes VE, Dallal RM, Hoekstra JB, Holleman F. Ethnic Differences in Weight Loss and Diabetes Remission After Bariatric Surgery A meta analysis. Diabetes Care. 2012;35(9):1951-1958. It has been postulated that the effectiveness of bariatric surgery varies between ethnic groups. However, data regarding this topic are inconclusive, as most studies included few patients from minority groups.

NHANES: Obesity Prevalence and BMI Trends Among US Children and Adolescents, 2009-2010

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Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010. JAMA. 2012;307(5):483-490. The National Health and Nutrition Examination Survey (NHANES) is a nationally representative sample of US civilian noninstituationalized population. The survey has run continuously since 1999, with data released in 2-year cycles.

NHANES: Obesity Prevalence and BMI Trends Among US Adults, 2009-2010

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Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA. 2012;307(5):491-497. The National Health and Nutrition Examination Survey (NHANES) is a nationally representative sample of US civilian noninstituationalized population. The survey has run continuously since 1999, with data released in 2-year cycles.

CONQUER: Safety, Efficacy of Phentermine + Topiramate for Weight Reduction Among Overweight or Obese Individuals with Weight-Related Comorbidities

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Gadde KM, Allison DB, Ryan DH, et al. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet. 2011;377:1341-1352. The CONQUER study was a randomized, double-blind, placebo-controlled study that evaluated the safety and efficacy of once-daily, controlled-release phentermine plus topiramate for weight reduction among those who were overweight or obese and had weight-related comorbidities.

ARIC Study: Examining Hypertension Risk Based on A1C

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Bower JK, Appel JL, Matsushita K, et al. ARIC Study: Examining Hypertension Risk Based on A1C. Diabetes Care. 2012;35:1031-1037. Bower and colleagues examined the role of A1C as a predictor of hypertension among subjects with and without diabetes in the Atherosclerosis Risk in Communities (ARIC) study.

Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study(2)

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Long term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes StudyThe Diabetes Prevention Program Research Group. Diabetes Care. 2012 35 731 737. Results from the Diabetes Prevention Program (DPP) study (a randomized, double-blind trial of metformin or placebo) and its long-term follow-up, the DPP Outcomes Study (DPPOS; an open-label extension of metformin and analysis of adverse events, tolerability, and effects of adherence on weight change and waist circumference) demonstrated a reduction in the development of diabetes among subjects treated with metformin.

Correlates of age onset of type 2 diabetes among relatively young black and white adults in a community: the Bogalusa Heart Study

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Nguyen QM, Xu JH, Chen W, Srinivasan SR, Berenson GS. Correlates of age onset of type 2 diabetes among relatively young black and white adults in a community the Bogalusa Heart Study. Diabetes Care. 2012;35(6):1341-1346. OBJECTIVE: The risk factors for middle-age onset of type 2 diabetes are well known. However, information is scant regarding the age onset of type 2 diabetes and its correlates in community-based black and white relatively young adults.

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