ACCORD

Effect of hypoglycemia on brain structure in people with type 2 diabetes: epidemiological analysis of the ACCORD-MIND MRI trial

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Zhang Z, Lovato J, Battapady H, et al. Effect of hypoglycemia on brain structure in people with type 2 diabetes:  epidemiological analysis of the ACCORD MIND MRI trial. Diabetes Care. 2014;37(12):3279-3285.

Low HDL cholesterol and the risk of diabetic nephropathy and retinopathy.

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Exclusive! Expert commentary webcast from Vivian Fonseca, MD, on this post-hoc analysis of ADVANCE. Morton J, Zoungas S, Li Q, et al; on behalf of the ADVANCE Collaborative Group. Low HDL cholesterol and the risk of diabetic nephropathy and retinopathy. Diabetes Care. 2012;35:2201-2206. Macro- and microvascular complications remain significant concerns in the treatment of patients with type 2 diabetes.

Four-year weight losses in the Look AHEAD study: factors associated with long-term success

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Alert: October 20, 2012: The Look AHEAD trial has been halted due to futility. Read exclusive commentary from Anne Peters, MD, one of the study’s principal investigators, on the important role of lifestyle interventions for preventing obesity and diabetes despite the lack of CV benefit seen in the trial. Wadden TA, Neiberg RH, Wing RR, et al; for the Look AHEAD Research Group. Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity. 2011;19(10):1987-1998. This analysis of 4-year data from the Look AHEAD (Action for Health in Diabetes) trial examined the effect of lifestyle on weight loss and identified demographic characteristics and lifestyle behaviors associated with sustained weight loss in the intensive lifestyle intervention treatment group.

Effects of intensive blood-pressure control in type 2 diabetes mellitus.

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ACCORD Study Group, Cushman WC, Evans GW, Byington RP, et al. Effects of intensive blood pressure control in type 2 diabetes mellitus. N Engl J Med. 2010;362(17):1575-1585. The blood-pressure (BP) arm of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study evaluated the effects of intensive BP-control on cardiovascular disease (CVD) events among high-risk subjects with type 2 diabetes.

Effects of intensive glucose lowering in type 2 diabetes

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The Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358(24):2545-2559. The Action to Control Cardiovascular Risk in Diabetes (ACCORD) study investigated the effects of intensive glucose-lowering therapy on CV event reduction among patients with type 2 diabetes and either risk factors for, or established, cardiovascular disease.

Fenofibrate-associated changes in renal function and relationship to clinical outcomes among individuals with type 2 diabetes: the ACCORD experience

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Bonds DE, Craven TE, Buse J, Crouse JR, Cuddihy R, Elam M, Ginsberg HN, Kirchner K, Marcovina S, Mychaleckyj JC, O'Connor PJ, Sperl-Hillen JA. Fenofibrate associated changes in renal function and relationship to clinical outcomes among individuals with type 2 diabetes the Action to Control Cardiovascular Risk in Diabetes (ACCORD) experience. Diabetologia. 2012 Mar 27. Epub ahead of print. Fenofibrate has been noted to cause an elevation in serum creatinine in some individuals.

The impact of frequent and unrecognized hypoglycemia on mortality in the ACCORD study

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Seaquist ER, Miller ME, Bonds DE for the ACCORD Investigators. The impact of frequent and unrecognized hypoglycemia on mortality in the ACCORD study. Diabetes Care. 2012 35(2) 409 414.  Seaquist and colleagues examined data from an Action to Control Cardiovascular Risk in Diabetes (ACCORD) substudy to explore the relationship between frequent and unrecognized hypoglycemia and mortality.

Effectiveness of lifestyle interventions for individuals with severe obesity and type 2 diabetes: results from the Look AHEAD trial

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Unick JL, Beavers D, Jakicic JM, et al; for the Look AHEAD Research Group. Effectiveness of lifestyle interventions for individuals with severe obesity and type 2 diabetes. Diabetes Care. 2011;34(10):2152-2157. This study by Unick and colleagues examined 1-year results from the Action for Health in Diabetes (Look AHEAD) trial, which assessed weight loss, changes in cardiovascular disease risk factors, and compliance with diet and fitness recommendations among overweight/obese subjects stratified by body mass index (BMI).

The effect of intensive risk factor management in type 2 diabetes on inflammatory biomarkers

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Samaropoulos XF, Light L, Ambrosius WT, Marcovina SM, Probstfield J, Jr DC. The effect of intensive risk factor management in type 2 diabetes on inflammatory biomarkers. Diabetes Res Clin Pract. 2011 Oct 21. [Epub ahead of print]. To determine whether intensive risk factor management reduced markers of inflammation in middle-aged and older people with type 2 diabetes who either had, or were at risk for cardiovascular disease (CVD), and whether these effects were mediated by adiposity.

Slowing cardiovascular disease progression in African-American patients: diabetes management

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Gavin JR, III. Slowing cardiovascular disease progression in African-American patients: diabetes management. J Clin Hypertens (Greenwich). 2004;6:26-33. The prevalence of type 2 diabetes has grown to epidemic proportions in the United States and is disproportionately higher in certain ethnic groups. African Americans, Hispanic Americans, Native Americans, and Asian Americans have an approximately two-fold higher rate of type 2 diabetes than whites.

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