2002

Usefulness of Home Blood Pressure Measurement in the Morning in Type 2 Diabetic Patients

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Kamoi K, Miyakoshi M, Soda S, Kaneko S, Nakagawa O. Usefulness of Home Blood Pressure Measurement in the Morning in Type 2 Diabetic Patients. Diabetes Care. 2002;25:2218-2223. Recently, repeated home blood pressure (HBP) measurements in the morning for a long period have been shown to have a stronger predictive power for mortality in patients with hypertension than occasional casual/clinic blood pressure (CBP) measurements. We studied whether HBP in the morning in type 2 diabetic patients is useful for prediction of diabetic complications.

UKPDS 59: Hyperglycemia and Other Potentially Modifiable Risk Factors for Peripheral Vascular Disease in Type 2 Diabetes

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Adler AI, Stevens RJ, Neil A, et al. UKPDS 59: Hyperglycemia and Other Potentially Modifiable Risk Factors for Peripheral Vascular Disease in Type 2 Diabetes. Diabetes Care. 2002;25:894-899. To determine the role of hyperglycemia in prospective analyses of peripheral vascular disease (PVD) in type 2 diabetes, taking into account other potential risk factors.

Type 2 Diabetes and Metabolic Syndrome in Filipina-American Women: A High-risk Nonobese Population

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Maria Rosario G. Araneta, PhD, Deborah L. Wingard, PhD and Elizabeth Barrett-Connor, MD. Type 2 Diabetes and Metabolic Syndrome in Filipina-American Women: A High-risk Nonobese Population. Diabetes Care. 2002;25:494-499. To compare the prevalence of type 2 diabetes and features of the metabolic syndrome among Filipina and Caucasian women in San Diego County, California.

The Relative Contributions of Birth Weight, Weight Change, and Current Weight to Insulin Resistance in Contemporary 5-Year-Olds

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Wilkin TJ, Metcalf BS, Murphy MJ, Kirkby J, Jeffery AN, Voss LD. The Relative Contributions of Birth Weight, Weight Change, and Current Weight to Insulin Resistance in Contemporary 5-Year-Olds. Diabetes. 2002;51:3468-3472. For more than a decade, the fetal programming hypothesis has taught that insulin resistance and its associated metabolic disturbances result from poor gestational environment, for which low birth weight is a surrogate. Low birth weight, however, is now uncommon in industrialized societies.

The Influence of Maternal BMI and Age in Twin Pregnancies on Insulin Resistance in the Offspring

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Loos RJF, Phillips DIW, Fagard R, et al. The Influence of Maternal BMI and Age in Twin Pregnancies on Insulin Resistance in the Offspring. Diabetes Care. 2002;25:2191-2196. There is strong evidence that low birth weight is associated with glucose intolerance and diabetes in adults. We have carried out a twin study to distinguish among maternal influences, which affect both twins; fetoplacental influences, which are unique to each twin; and the genetic factors that may underlie this association.

The In Vivo Regulation of Pulsatile Insulin Secretion

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N. Porksen. The In Vivo Regulation of Pulsatile Insulin Secretion. Diabetologia. 2002;45:3-20. The presence of oscillations in peripheral insulin concentrations has sparked a number of studies evaluating the impact of the insulin release pattern on the action of insulin on target organs. These have convincingly shown that equal amounts of insulin presented to target organs have improved action when delivered in a pulsatile manner.

The Impact of Planned Care and a Diabetes Electronic Management System on Community-Based Diabetes Care

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Montori VM, Dinneen SF, Gorman CA, et al. The Impact of Planned Care and a Diabetes Electronic Management System on Community-Based Diabetes Care: The Mayo Health System Diabetes Translation Project. Diabetes Care. 2002;25:1952-1957. The Mayo Health System Diabetes Translation Project sought to assess models of community-based diabetes care and use of a diabetes electronic management system (DEMS). Planned care is a redesigned model of chronic disease care that involves guideline implementation, support of self-management, and use of clinical information systems.

The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes

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Mayerson AB, Hundal RS, Dufour S, et al. The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes. Diabetes. 2002;51:797-802. We examined the effect of three months of rosiglitazone treatment (4 mg b.i.d.) on whole-body insulin sensitivity and in vivo peripheral adipocyte insulin sensitivity as assessed by glycerol release in microdialysis from subcutaneous fat during a two-step (20 and 120 mU m-2 min-1) hyperinsulinemic-euglycemic clamp in nine type 2 diabetic subjects.

The Diabetes Prevention Program (DPP): Description of Lifestyle Intervention

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The Diabetes Prevention Program (DPP) Research Group. The Diabetes Prevention Program (DPP): Description of Lifestyle Intervention. Diabetes Care. 2002;25:2165-2171. The purpose of the present article is to provide a detailed description of the highly successful lifestyle intervention administered to 1,079 participants, which included 45% racial and ethnic minorities and resulted in a 58% reduction in the incidence rate of diabetes (2).

Rosiglitazone Inhibits the Jun NH(2)-Terminal Kinase/Activating Protein 1 Pathway and Protects the Heart from Ischemia/Reperfusion Injury

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Khandoudi N, Delerive P, Berrebi-Bertrand I, Buckingham RE, Staels B, Bril A. Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-Gamma, Inhibits the Jun NH(2)-Terminal Kinase/Activating Protein 1 Pathway and Protects the Heart from Ischemia/Reperfusion Injury. Diabetes. 2002;51:1507-1514. This study was conducted to evaluate whether treatment of normal and diabetic rat hearts with rosiglitazone, a high-affinity ligand of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) used for the treatment of type 2 diabetes, improves postischemic functional recovery.

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