2011

Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy

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The AIM-HIGH Investigators. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med. 2011;365(24):2255-2267. Residual cardiovascular (CV) risk persists among high-risk patients despite achievement of target LDL-C levels. In addition to elevated LDL-C, low HDL-C has been found in epidemiological studies to independently predict coronary heart disease (CHD) risk.

CONQUER: Safety, Efficacy of Phentermine + Topiramate for Weight Reduction Among Overweight or Obese Individuals with Weight-Related Comorbidities

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Gadde KM, Allison DB, Ryan DH, et al. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet. 2011;377:1341-1352. The CONQUER study was a randomized, double-blind, placebo-controlled study that evaluated the safety and efficacy of once-daily, controlled-release phentermine plus topiramate for weight reduction among those who were overweight or obese and had weight-related comorbidities.

Long-term treatment with the dipeptidyl peptidase-4 inhibitor saxagliptin in patients with type 2 diabetes mellitus and renal impairment

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Nowicki M, Rychlik I, Haller H, et al. Int J Clin Pract . Long-term treatment with the dipeptidyl peptidase-4 inhibitor saxagliptin in patients with type 2 diabetes mellitus and renal impairment: a randomised controlled 52-week efficacy and safety study. 2011;65(12):1230-1239. Nowicki and colleagues examined the effects of the dipeptidyl peptidase-4 (DPP-4) inhibitor, saxagliptin, among patients with inadequately controlled type 2 diabetes and renal impairment in a 52-week study.

Wound healing and treatments for people with diabetic foot ulcers

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Jeffcoate WJ, Price P, Harding KG. Wound healing and treatments for people with diabetic foot ulcers. Diabetes Metab Res Rev. 2004;20(suppl 1):S78-S89. The factors that delay wound healing are multiple and relate both to diabetes and to the effect of its complications. Diabetic foot ulcers readily become chronic, and chronic ulcers have biological properties that differ substantially from acute ones.

Whole-Blood Glucose Testing at Alternate Sites: Glucose Values and Hematocrit of Capillary Blood Drawn From Fingertip and Forearm

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Lock JP, Szuts EZ, Malomo KJ, Anagnostopoulos A. White-blood glucose testing at alternate sites: glucose values and hematocrit of capillary blood drawn from fingertip and forearm. Diabetes Care. 2002;52:337-341. To measure hematocrit (Hct) and glucose concentration in capillary blood drawn from the fingertip and forearm of a group of 50 nonfasting subjects with diabetes.

White Blood Cell Count Is Associated With Macro- and Microvascular Complications in Chinese Patients With Type 2 Diabetes

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Tong PC, Lee K-F, So W-Y, et al. White blood cell count is associated with macro- and microvascular complications in Chinese patients with type 2 diabetes. Diabetes Care. 2004;27:216-222. OBJECTIVES: There are close associations among raised white blood cell (WBC) count, coronary heart disease, and metabolic syndrome in the general population. The association between WBC count and vascular complications of diabetes has not been explored. We carried out a cross-sectional cohort study to determine the association between WBC count and the presence of macro- and microvascular complications in type 2 diabetes.

What is the most effective strategy for managing diabetic dyslipidaemia?

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Reasner CA. What is the most effective strategy for managing diabetic dyslipidemia? Atheroscler Suppl. 2005;6:21-27. The dyslipidaemic profile of diabetes greatly contributes to the increased cardiovascular risk associated with the disorder, and evidence from many intervention trials using statins, fibrates, nicotinic acid or a nicotinic acid-statin combination, indicates the substantial cardiovascular risk reduction to be gained from lipid modification.

What is the consequence of an abnormal lipid profile in patients with type 2 diabetes or the metabolic syndrome?

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Windler E. What is the consequence of an abnormal lipid profile in patients with type 2 diabetes or the metabolic syndrome? Atheroscler Suppl. 2005;6:11-14. Patients with type 2 diabetes have an atherogenic lipid profile, which greatly increases their risk of coronary heart disease (CHD) compared with people without diabetes.

What Is an Optimal Diet? Relationship of Macronutrient Intake to Obesity, Glucose Tolerance, Lipoprotein Cholesterol Levels & Metabolic Syndrome

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Brunner EJ, Wunsch H, Marmot MG. What is an optimal diet? Relatinoship of macronutrient intake to obesity, glucose tolerance, lipoprotein cholesterol levels and the metabolic syndrome in the Whitehall II Study. Int J Obesity. 2001;25:45-53. OBJECTIVE: Saturated fats have adverse effects on health. To investigate which is more beneficial for energy replacement, we compare the effects of polyunsaturated fatty acid and carbohydrate intake on obesity and metabolic variables (fasting triglycerides, HDL-cholesterol, LDL-cholesterol and 2 h glucose).

What are incretins, and how will they influence the management of type 2 diabetes?

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Blonde L, Rosenstock J. Triplitt C. What are incretins, and how will they influence the management of type 2 diabetes? J Manag Care Pharm. 2006;12(7 Suppl A):2-12. To review the pathophysiology of type 2 diabetes (T2DM), the role of incretins, the potential of incretin-based therapies to address unmet therapeutic needs in T2DM, and the potential impact this will have on the contribution of managed care pharmacy to diabetes therapy.

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