The Natural Course of {beta}-Cell Function in Nondiabetic and Diabetic Individuals: The Insulin Resistance Atherosclerosis Study

Festa A, Williams K, D'Agostino R, Jr., Wagenknecht LE, Haffner SM 

Data from the UKPDS (U.K. Prospective Diabetes Study) indicate a continuous decline in beta-cell function in patients with type 2 diabetes. We studied longitudinal changes in beta-cell function (follow-up of 5.2 years) in subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes, using acute insulin response (AIR) and insulin sensitivity index (S(i)) from a frequently sampled intravenous glucose tolerance test among African-American, Hispanic, and non-Hispanic white subjects aged 40-69 years.  (more) 

 


Festa A, Williams K, D'Agostino R, Jr., Wagenknecht LE, Haffner SM. The Natural Course of Beta-Cell Function in Nondiabetic and Diabetic Individuals: The Insulin Resistance Atherosclerosis Study. Diabetes. 2006;55:1114-1120. 

Last Modified: 3/1/2013