Postprandial blood glucose predicts cardiovascular events and all-cause mortality in type 2 diabetes in a 14-year follow-up

Postprandial blood glucose predicts cardiovascular events and all-cause mortality in type 2 diabetes in a 14-year follow-up: lessons from the San Luigi Gonzaga Diabetes Study.
Cavalot F, Pagliarino A, Valle M, et al.
Diabetes Care. 2011;34(10):2237-2

Cavalot F, Pagliarino A, Valle M, et al.
Diabetes Care. 2011;34(10):2237-2243. 

This overview was created under the auspices of KnowledgePoint360 Group, LLC, and was not associated with funding via an educational grant or a promotional interest. 

Cavalot and colleagues conducted a 14-year follow-up of the San Luigi Gonzaga Diabetes Study to assess the role of postprandial blood glucose in predicting CV events and all-cause mortality among subjects with type 2 diabetes. This follow-up study included 505 subjects that were enrolled in initial 5-year study. 

Subjects were measured for five glycemic control parameters as part of the initial study: blood glucose levels before (fasting) and 2 hours after breakfast, 2 hours after lunch, and before dinner, and A1C. Of those enrolled in the follow-up study, at baseline: 

  • 16.8% had history of CV events 
  • 44.6% were on diet alone 
  • 43.0% were receiving oral agents 
  • 7.3% were receiving oral agents + insulin 
  • 5.1% were receiving insulin alone 

Over 14 years of follow-up, 172 subjects (34.1%) experienced a first CV event and there were 147 deaths (29.1% of the study population). A breakdown of CV events is shown below.  

CV Event Breakdown  
96 coronary events
(55.8% of study population)
36 myocardial infarctions, 45 revascularizations, 6 unstable anginas, 9 sudden deaths
55 cerebrovascular events
(31.9% of study population)
25 transient ischemic attacks, 20 strokes, 10 carotid thrombo-endoarterectomies
21 peripheral events
(12.2% of study population)
16 lower-limb revascularizations, 2 operations for aortic aneurisms, 3 amputations for lower-limb ischemia

This overview was created under the auspices of KnowledgePoint360 Group, LLC, and was not associated with funding via an educational grant or a promotional interest. 

 

43. 

 

This overview was created under the auspices of KnowledgePoint360 Group, LLC, and was not associated with funding via an educational grant or a promotional interest. 

Cavalot and colleagues conducted a 14-year follow-up of the San Luigi Gonzaga Diabetes Study to assess the role of postprandial blood glucose in predicting CV events and all-cause mortality among subjects with type 2 diabetes. This follow-up study included 505 subjects that were enrolled in initial 5-year study. 

Subjects were measured for five glycemic control parameters as part of the initial study: blood glucose levels before (fasting) and 2 hours after breakfast, 2 hours after lunch, and before dinner, and A1C. Of those enrolled in the follow-up study, at baseline: 

  • 16.8% had history of CV events 
  • 44.6% were on diet alone 
  • 43.0% were receiving oral agents 
  • 7.3% were receiving oral agents + insulin 
  • 5.1% were receiving insulin alone 

Over 14 years of follow-up, 172 subjects (34.1%) experienced a first CV event and there were 147 deaths (29.1% of the study population). A breakdown of CV events is shown below.  

CV Event Breakdown  
96 coronary events
(55.8% of study population)
36 myocardial infarctions, 45 revascularizations, 6 unstable anginas, 9 sudden deaths
55 cerebrovascular events
(31.9% of study population)
25 transient ischemic attacks, 20 strokes, 10 carotid thrombo-endoarterectomies
21 peripheral events
(12.2% of study population)
16 lower-limb revascularizations, 2 operations for aortic aneurisms, 3 amputations for lower-limb ischemia

This overview was created under the auspices of KnowledgePoint360 Group, LLC, and was not associated with funding via an educational grant or a promotional interest. 

 

Last Modified: 2/19/2013