Parental history of type 2 diabetes mellitus, metabolic syndrome, and cardiometabolic risk factors in Asian Indian adolescents

The objective was to study the influence of parental history of type 2 diabetes mellitus on prevalence of the metabolic syndrome (MS) and other cardiometabolic risk factors in Asian Indian adolescents. Adolescents aged 12 to 19 years (n=321) were recruited from the Chennai Urban Rural Epidemiology Study. Based on parental diabetic status, 3 groups were studied: group 1, offspring of parents with normal glucose tolerance (n=105); group 2, offspring of 1 diabetic parent (n=114); and group 3, offspring of 2 diabetic parents (n=102). Subjects underwent blood pressure and anthropometric measurements as well as an oral glucose tolerance test and a fasting lipid profile. Metabolic syndrome was diagnosed using the International Diabetes Federation definition. Body mass index (P<0.001) and waist and hip circumference (P<0.05 for group 2 and P<0.001 for group 3) were significantly higher in groups 2 and 3 compared with group 1. High-density lipoprotein cholesterol was significantly lower in groups 2 and 3 compared with group 1 (P<0.05). Serum triglycerides were significantly higher in group 3 (P<0.05) compared with the other 2 groups. Adolescents in group 3 (P<0.001) and group 2 (P<0.05) were significantly more overweight and had more abdominal obesity compared with those in group 1. Impaired fasting glucose and impaired glucose tolerance were also significantly higher in group 3 compared with the other 2 groups. High blood pressure showed an increasing trend from group 1 to group 3 (P for trend <0.05). Two metabolic abnormalities were present in 7.6%, 14.9%, and 22.5% of adolescents in groups 1, 2, and 3, respectively (trend chi(2): 9.04, P=0.003). Prevalence of MS was higher in groups 2 and 3 compared with group 1 but did not reach statistical significance because of small numbers. The cardiometabolic profile of the parents was similar to that of the adolescents. Parental history of type 2 diabetes mellitus increases risk of not only glucose intolerance but also other cardiometabolic risk factors like overweight, low high-density lipoprotein cholesterol, and high blood pressure in Asian Indian adolescents. 

PMID: 19217449 [PubMed - indexed for MEDLINE] 

 


Anjana RM, Lakshminarayanan S, Deepa M, Farooq S, Pradeepa R, Mohan V. Parental history of type 2 diabetes mellitus, metabolic syndrome, and cardiometabolic risk factors in Asian Indian adolescents. Metabolism. 2009;58(3):344-350. 

Last Modified: 2/8/2013