Severe hypoglycaemia and cardiovascular disease: systematic review and meta-analysis with bias analysis

Goto A, Onyebuchi AA, Goto M, Terauchi Y, Noda M. Severe hypoglycaemia and cardiovascular disease: systematic review and meta-analysis with bias analysis. BMJ. 2013;347:f4533 doi: 10.1136/bmj.f4533.

Data from a meta-analysis showed that severe hypoglycemia was associated with nearly twice the risk for cardiovascular disease (CVD): relative risk 2.05, 95% confidence interval 1.74 to 2.42; P<0.001.

Severe hypoglycemia occurred in 0.6% to 5.8% of subjects during follow-up. When a bias analysis was conducted, findings showed that the association seen between severe hypoglycemia and CVD may not be entirely due to confounding by severe comorbid illness: comorbid severe illness would had to have been extremely strongly associated with both severe hypoglycemia and CVD. Moderate heterogeneity was seen between studies (I2=73.1%; P=0.002 for heterogeneity); however most of the subgroups examined showed similar results in stratified analyses.

The analysis included six cohort studies of patients with type 2 diabetes (N=903,510). Mean diabetes duration was 3.2-11.5 years and mean study follow-up was 1 to 5.6 years.

Click on slide to view larger.
 09 - Meta-Analysis Severe Hypoglycemia
 

   

September 2013 

This overview was created by KnowledgePoint360 Group, LLC, and was not associated with funding via an educational grant or a promotional/commercial interest.  

Previous Article
Comparative tolerability and harms of individual statins. A study-level network meta-analysis of 246,955 participants from 135 randomized, controlled trials 

Next Article
Roux-en-Y gastric bypass vs intensive medical management for the control of type 2 diabetes, hypertension, and hyperlipidemia 

Back to
Recent Diabetes Articles 

BG Footer

 

 

Last Modified: 8/4/2014