Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI?

Biessels GJ, Reijmer YD. Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI? Diabetes. 2014. DOI:10.2337/db14-0384.

Key points: 

  • Decreased cognitive function, increased dementia risk seen in people with type 2 diabetes
  • Type 2 diabetes linked to brain MRI abnormalities
    • Abnormalities include: global cortical and subcortical atrophy, and increased small-vessel disease burden
      • Small-vessel disease may contribute to abnormalities in functional and structural connectivity <-- linked to cognitive dysfunction
       
     
  • Potentially modifiable risk factors: chronic hyperglycemia exposure, insulin resistance, hypertension and other vascular risk factors
  • Other factors that may play a role: inflammation, oxidative stress, hypoperfusion, Alzheimer-type degenerative processes
  • Currently no place for brain MRI in evaluation of patients with type 2 diabetes
    • No typical MRI indicative of type 2 diabetes in an individual patient
     
Click on slide thumbnail to view larger. Slide available for download in the slide library.
Abnormalities in Brain MRI May Underlie Cognitive Dysfunction in Patients With Type 2 Diabetes  
Abnormalities in Brain MRI May Underline Cognitive Dysfunction in Patients With Type 2 Diabetes 

 

  



June 2014 

This overview was created by KnowledgePoint360 Group, LLC, and was not associated with funding via an educational grant or a promotional/commercial interest.  

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Last Modified: 8/4/2014