Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease

De Felice FG, Ferreira ST. Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes. 2014. DOI:10.2337/db13-1954.

Key points: 

  • Increased risk of developing Alzheimer disease in patients with type 2 diabetes, and vice versa
    • Data have shown two-fold increased frequency of dementia and neurological disorders in individuals with diabetes vs those without
    • Incidence of other neurological disorders, such as vascular pathology and stroke, also appear to be doubled in patients with type 2 diabetes vs those without
     
  • Consistent elevations in glucose have a negative impact on the brain – even if no overt type 2 diabetes or impaired glucose tolerance
    • Elevated glucose increases dementia risk in individuals with and without diabetes; association with cognitive decline and reduced hippocampal volume also seen
     
  • Shared features of type 2 diabetes and Alzheimer disease: insulin resistance, inflammation, mitochondrial dysfunction
  • Both inflammatory and metabolic components may play a role in the connection between type 2 diabetes and Alzheimer disease
    • Poor lifestyle habits may also factor in to the connection: these can predispose persons to type 2 diabetes and obesity and may play a role in Alzheimer disease susceptibility
     
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Connections Between Type 2 Diabetes and Alzheimer Disease  
Connections Between Type 2 Diabetes and Alzheimer Disease 

 

  



June 2014 

This overview was created by KnowledgePoint360 Group, LLC, and was not associated with funding via an educational grant or a promotional/commercial interest.  

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Last Modified: 8/4/2014