Low HDL cholesterol ass’d w/ the risk of stroke in elderly diabetic individuals: changes in the risk for atherosclerotic diseases at various ages

OBJECTIVE: To clarify the relationship between lipid levels and ischemic heart disease (IHD) and cerebrovascular disease (CVD) in diabetic individuals. RESEARCH DESIGN AND METHODS: The Japan Cholesterol and Diabetes Mellitus Study is a prospective cohort study of 4,014 type 2 diabetic patients (1,936 women; mean &plusmn; SD age 67.4 &plusmn; 9.5 years). Lipid and glucose levels and other factors were investigated in relation to occurrence of IHD or CVD. RESULTS: IHD and CVD occurred in 1.59 and 1.43% of participants, respectively, over a 2-year period. The relation of lower HDL or higher LDL cholesterol to occurrence of IHD in subjects <65 years old was significant. Lower HDL cholesterol was also significantly related to CVD in subjects =65 years old and especially in those >75 years old (n=1,016; odds ratio 0.511 [95% CI 0.239-0.918]; P<0.05). Stepwise multiple regression analysis with onset of CVD as a dependent variable showed the same result. CONCLUSIONS: Lower HDL cholesterol is an important risk factor for not only IHD but also CVD, especially in diabetic elderly individuals. 

PMID: 19509009 [PubMed - in process] 

PMCID: PMC2699721 [Available on 2010/07/01] 

 


Hayashi T, Kawashima S, Itoh H, et al, for the Japan CDM Group. Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals: changes in the risk for atherosclerotic diseases at various ages. Diabetes Care. 2009;32(7):1221-1223. 

Last Modified: 2/5/2013