Poor glycemic control is an independent risk factor for low HDL-C in patients with type 2 diabetes

Objective: To determine whether the association observed between poor glycemic control and low HDL-Cholesterol (HDL-C) in type 2 diabetes is dependent on obesity and/or hypertriglyceridemia. Research design and methods: We performed a cross-sectional study of 1819 patients with type 2 diabetes and triglycerides <400 mg/dl enrolled in three Italian centers. The risk for low HDL-C was analyzed as a function of A1C levels. Odds ratios were calculated after adjustment for confounding factors. Results: A 1% increase in A1C significantly increased the risk for low HDL-C (OR=1.17, 95% CI 1.1-1.2; P=0.00072); no changes were observed when age, sex, smoking, and lipid-lowering therapy were included in the model (OR=1.17, 95% CI 1.1-1.2) (P=0.00044). The association remained strong after adjustment for obesity and hypertriglyceridemia in multivariate analysis (OR=1.12, 95% CI=1.05-1.18; P=0.00017). Conclusions: Poor glycemic control appears to be an independent risk factor for low HDL-C in type 2 diabetes. 

PMID: 19487641 [PubMed - as supplied by publisher] 

  


Gatti A, Maranghi M, Bacci S, et al. Poor glycemic control is an independent risk factor for low HDL-C in patients with type 2 diabetes. Diabetes Care. 2009 Jun 1. [Epub ahead of print]. 

Last Modified: 2/19/2013