Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an ASCOT substudy

OBJECTIVE: To study the association of the inflammatory markers serum amyloid A (SAA) and C-reactive protein (CRP) with retinal microvascular parameters in hypertensive individuals with and without type 2 diabetes. RESEARCH DESIGN AND METHODS: This cross-sectional analysis was a substudy in 711 patients (159 with and 552 without diabetes) of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) based on digital 30-degree images of superior and inferior temporal retinal fields. RESULTS: SAA was associated with arteriolar length-to-diameter ratio positively in nondiabetic patients (P=0.028) but negatively in diabetic patients (P=0.005). The difference was unlikely to be a chance finding (P=0.007 for interaction). Similar results were found for the association of SAA with arteriolar tortuosity (P=0.05 for interaction). Associations were less pronounced for CRP and retinal parameters. CONCLUSIONS: Inflammatory processes are differentially involved in retinal microvascular disease in diabetic compared with nondiabetic hypertensive individuals. 

PMID: 19244088 [PubMed - in process] 

PMCID: PMC2681044 [Available on 2010/06/01] 

 


Stettler C, Witt N, Tapp RJ, et al. Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy.. Diabetes Care. 2009;32(6):1098-1100. 

Last Modified: 2/26/2013