Thiazolidinedione (Pioglitazone) blocks P. gingivalis- and F. nucleatum but not E. coli lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) production

Yamaguchi M, Nishimura F, Naruishi H, Soga Y, Kokeguchi S, Takashiba S 

An elevated level of C-reactive protein (CRP) predicts the future development of coronary heart disease. Periodontitis appears to up-regulate CRP. CRP is produced by hepatocytes in response to interleukin-6 (IL-6). A major source of IL-6 in obese subjects is adipocytes. 

 

 


Yamaguchi M, Nishimura F, Naruishi H, Soga Y, Kokeguchi S, Takashiba S. Thiazolidinedione (Pioglitazone) blocks P. gingivalis- and F. nucleatum, but not E. coli, lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) production in adipocytes. J Dent Res. 2005;84:240-244. 

Last Modified: 3/1/2013